Title : Apoptosis induced by paclitaxel via Bcl-2, Bax and caspases 3 and 9 activation in NB4 human leukaemia cells is not modulated by ERK inhibition.

Pub. Date : 2013 Nov

PMID : 23735541






2 Functional Relationships(s)
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1 Apoptosis induced by paclitaxel via Bcl-2, Bax and caspases 3 and 9 activation in NB4 human leukaemia cells is not modulated by ERK inhibition. Paclitaxel BCL2 associated X, apoptosis regulator Homo sapiens
2 Decrease of p53 and Bcl-2, fragmentation of DNA, increase of Bax and, finally, activation of caspases 3 and 9 in NB4 leukaemia cells make the apoptotic process induced by Ptx irreversible. Paclitaxel BCL2 associated X, apoptosis regulator Homo sapiens