Title : Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator.

Pub. Date : 2013 Aug 1

PMID : 23732298






2 Functional Relationships(s)
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1 In this study, we have investigated a possible involvement of liver X receptor alpha (LXRalpha), a critical regulator of cholesterol homeostasis, in the hepatic CYP3A4 expression since several recent reports suggest the involvement of CYP3A enzymes in the cholesterol metabolism in humans and mice. Cholesterol nuclear receptor subfamily 1 group H member 3 Homo sapiens
2 In this study, we have investigated a possible involvement of liver X receptor alpha (LXRalpha), a critical regulator of cholesterol homeostasis, in the hepatic CYP3A4 expression since several recent reports suggest the involvement of CYP3A enzymes in the cholesterol metabolism in humans and mice. Cholesterol nuclear receptor subfamily 1 group H member 3 Homo sapiens