Pub. Date : 2013 Aug
PMID : 23729436
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Indapamide increased kidney CYP2C23 expression, decreased soluble epoxide hydrolase expression, increased urinary and renovascular 11,12- and 14,15-EETs, and decreased production of 11,12- and 14,15-dihydroxyeicosatrienoic acids in SHRs. | Indapamide | cytochrome P450, family 2, subfamily c, polypeptide 23 | Rattus norvegicus |
| 2 | No effect on expression of CYP4A1 or CYP2J3, or on 20-hydroxyeicosatetraenoic acid production, was observed, suggesting indapamide specifically targets CYP2C23-derived EETs. | Indapamide | cytochrome P450, family 2, subfamily c, polypeptide 23 | Rattus norvegicus |
| 3 | Furthermore, the p47phox-lowering effect of indapamide in angiotensin II-treated rat mesangial cells was partially blocked by the presence of N-(methylsulfonyl)-2-(2-propynyloxy)-benzenehexanamide (MS-PPOH) or CYP2C23 small interfering RNA. | Indapamide | cytochrome P450, family 2, subfamily c, polypeptide 23 | Rattus norvegicus |