Title : Opioid receptor selectivity profile change via isosterism for 14-O-substituted naltrexone derivatives.

Pub. Date : 2013 Jul 1

PMID : 23721804






2 Functional Relationships(s)
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1 A series of 14-O-substituted naltrexone derivatives were identified as potent mu opioid receptor (MOR) antagonists with improved selectivity over the kappa opioid receptor (KOR) and the delta opioid receptor (DOR), compared to naltrexone. Naltrexone opioid receptor kappa 1 Homo sapiens
2 A series of 14-O-substituted naltrexone derivatives were identified as potent mu opioid receptor (MOR) antagonists with improved selectivity over the kappa opioid receptor (KOR) and the delta opioid receptor (DOR), compared to naltrexone. Naltrexone opioid receptor kappa 1 Homo sapiens