Title : [Suppression of the growth of subcutaneous transplanted human liver cancer and lung metastasis in nude mice treated by sorafenib combined with fluorouracil].

Pub. Date : 2013 Feb

PMID : 23714662






2 Functional Relationships(s)
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1 Statistically, the expression of p-ERK, P-gp and Topo IIa in the Sorafenib group was significantly reduced compared with that of the control group (P < 0.05), and there was no significant difference in the expression of p-ERK, P-gp and Topo IIa between the sorafenib group and the combination treatment group (P > 0.05). Sorafenib phosphoglycolate phosphatase Mus musculus
2 CONCLUSIONS: Sorafenib can inhibit not only the tumor growth and lung metastsis in the nude mouse models, but also reduce the expression of multidrug resistance proteins P-gp and Topo IIa as well. Sorafenib phosphoglycolate phosphatase Mus musculus