Title : Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profile.

Pub. Date : 2013 Dec 1

PMID : 23707769






3 Functional Relationships(s)
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1 We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets. Ibogaine ETS transcription factor ERG Homo sapiens
2 We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets. Ibogaine ETS transcription factor ERG Homo sapiens
3 We confirmed that heterologously expressed hERG currents are reduced by ibogaine in low micromolar concentrations. Ibogaine ETS transcription factor ERG Homo sapiens