Title : Reduced selenium-binding protein 1 in breast cancer correlates with poor survival and resistance to the anti-proliferative effects of selenium.

Pub. Date : 2013

PMID : 23704933






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The antitumor function of selenium is thought to be mediated through selenium-binding protein 1 (SELENBP1). Selenium selenium binding protein 1 Homo sapiens
2 The antitumor function of selenium is thought to be mediated through selenium-binding protein 1 (SELENBP1). Selenium selenium binding protein 1 Homo sapiens
3 In addition, selenium treatment resulted in reduced cell proliferation in endogenous SELENBP1 high cells; however, after knocking-down SELENBP1, we observed no significant reduction in cell proliferation. Selenium selenium binding protein 1 Homo sapiens
4 These data indicate that SELENBP1 expression is regulated via estrogen and that the cell proliferation inhibition effect of selenium treatment is dependent on the high level of SELENBP1 expression. Selenium selenium binding protein 1 Homo sapiens
5 These data indicate that SELENBP1 expression is regulated via estrogen and that the cell proliferation inhibition effect of selenium treatment is dependent on the high level of SELENBP1 expression. Selenium selenium binding protein 1 Homo sapiens
6 Therefore, the expression level of SELENBP1 could be an important marker for predicting survival and effectiveness of selenium supplementation in breast cancer. Selenium selenium binding protein 1 Homo sapiens