Title : CDK inhibitors induce mitochondria-mediated apoptosis through the activation of polyamine catabolic pathway in LNCaP, DU145 and PC3 prostate cancer cells.

Pub. Date : 2014

PMID : 23701543






2 Functional Relationships(s)
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1 Although roscovitine was less effective in DU145 cells, pre-treatment with alpha-difluoromethylornithine (DFMO), an inhibitor of ODC, enhanced the roscovitine-induced apoptotic cell death through the cleavage of caspase-9 and caspase-3. Eflornithine caspase 3 Homo sapiens
2 Although roscovitine was less effective in DU145 cells, pre-treatment with alpha-difluoromethylornithine (DFMO), an inhibitor of ODC, enhanced the roscovitine-induced apoptotic cell death through the cleavage of caspase-9 and caspase-3. Eflornithine caspase 3 Homo sapiens