Pub. Date : 2013 Oct
PMID : 23692359
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users. | Nicotine | cholinergic receptor nicotinic alpha 5 subunit | Homo sapiens |
| 2 | We investigated CHRNA5-A3-B4 haplotype structure and its association with nicotine intake and obesity in Alaska Native people. | Nicotine | cholinergic receptor nicotinic alpha 5 subunit | Homo sapiens |
| 3 | In 290 Alaska Native tobacco users the "G" allele of rs578776, which tagged a 30 kb haplotype in CHRNA5-A3-B4, was prevalent (16%) and associated significantly with nicotine intake (20% higher plasma cotinine, P < 0.001, 16% higher TNE, P = 0.076), while rs16969968 was not associated with nicotine intake. | Nicotine | cholinergic receptor nicotinic alpha 5 subunit | Homo sapiens |
| 4 | In 290 Alaska Native tobacco users the "G" allele of rs578776, which tagged a 30 kb haplotype in CHRNA5-A3-B4, was prevalent (16%) and associated significantly with nicotine intake (20% higher plasma cotinine, P < 0.001, 16% higher TNE, P = 0.076), while rs16969968 was not associated with nicotine intake. | Nicotine | cholinergic receptor nicotinic alpha 5 subunit | Homo sapiens |
| 5 | CONCLUSIONS: Genetic variants in CHRNA5-A3-B4 alter nicotine intake and body mass index in a population of Alaska Native people, who have a distinct haplotype structure, smoking behaviors and prevalence of obesity. | Nicotine | cholinergic receptor nicotinic alpha 5 subunit | Homo sapiens |