Pub. Date : 2013
PMID : 23691077
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockade of presynaptic alpha2A-adrenergic receptor. | Yohimbine | adrenergic receptor, alpha 2a | Mus musculus |
| 2 | Immunohistochemical analysis revealed that cardiac alpha2A-AR was mostly located in sympathetic nerve presynaptic membrane; YHB decreased cardiac alpha2A-AR level and promoted cardiac norepinephrine (NE) release in endotoxemic mice. | Yohimbine | adrenergic receptor, alpha 2a | Mus musculus |
| 3 | Immunohistochemical analysis revealed that cardiac alpha2A-AR was mostly located in sympathetic nerve presynaptic membrane; YHB decreased cardiac alpha2A-AR level and promoted cardiac norepinephrine (NE) release in endotoxemic mice. | Yohimbine | adrenergic receptor, alpha 2a | Mus musculus |
| 4 | Altogether, these findings indicate that YHB attenuates LPS-induced cardiac dysfunction, at least in part, through blocking presynaptic alpha2A-AR and thus increasing cardiac NE release. | Yohimbine | adrenergic receptor, alpha 2a | Mus musculus |