Title : Suppressive effects of antimycotics on thymic stromal lymphopoietin production in human keratinocytes.

Pub. Date : 2013 Sep

PMID : 23688403






2 Functional Relationships(s)
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1 The antimycotics itraconazole, ketoconazole, luliconazole, terbinafine, butenafine, and amorolfine suppressed the secretion and mRNA expression of TSLP, NF-kappaB activity, and IkappaBalpha degradation induced by poly I:C plus IL-4. luliconazole interleukin 4 Homo sapiens
2 CONCLUSIONS: Antimycotics itraconazole, ketoconazole, luliconazole, terbinafine, butenafine, and amorolfine may suppress poly I:C plus IL-4-induced production of TSLP by inhibiting NF-kappaB via increasing 15d-PGJ2 production in keratinocytes. luliconazole interleukin 4 Homo sapiens