Title : A posttranslational modification cascade involving p38, Tip60, and PRAK mediates oncogene-induced senescence.

Pub. Date : 2013 Jun 6

PMID : 23685072






1 Functional Relationships(s)
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1 Upon activation by ras, p38 induces the acetyltransferase activity of Tip60 through phosphorylation of Thr158; activated Tip60 in turn directly interacts with and induces the protein kinase activity of PRAK through acetylation of K364 in a manner that depends on phosphorylation of both Tip60 and PRAK by p38. salinomycin MAPK activated protein kinase 5 Homo sapiens