Title : Biomimetic asymmetric 1,3-dioplar cycloaddition: amino acid precursors in biosynthesis serve as latent azomethine ylides.

Pub. Date : 2013 Jun 7

PMID : 23679128






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1 The first asymmetric catalytic biomimetic three-component 1,3-dipolar cycloaddition of alpha-keto esters and benzylamine with electron-deficient olefins, inspired by the transamination of alpha-keto acids involving pyridoxal phosphate (PLP)-dependent enzymes in biological systems, giving several families of structurally diverse pyrrolidine derivatives in high yields and excellent enantioselectivities (up to 99% ee) under mild conditions is described. alpha-keto acids pyridoxal phosphatase Homo sapiens