Pub. Date : 2013 Jul 15
PMID : 23677799
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines. | Disulfides | claudin 2 | Canis lupus familiaris |
| 2 | Immunoblotting showed a higher molecular mass band in the mutants with a single cysteine mutation, consistent with a claudin-2 dimer, suggesting that the two conserved cysteines normally form an intramolecular disulfide bond in wild-type claudin-2. | Disulfides | claudin 2 | Canis lupus familiaris |
| 3 | Immunoblotting showed a higher molecular mass band in the mutants with a single cysteine mutation, consistent with a claudin-2 dimer, suggesting that the two conserved cysteines normally form an intramolecular disulfide bond in wild-type claudin-2. | Disulfides | claudin 2 | Canis lupus familiaris |
| 4 | We conclude that the disulfide bond between the conserved extracellular cysteines in claudin-2 is necessary for pore formation, probably by stabilizing the ECL1 fold, but is not required for correct protein trafficking. | Disulfides | claudin 2 | Canis lupus familiaris |