Title : The neurokinin-3 receptor (NK3R) antagonist SB222200 prevents the apomorphine-evoked surface but not nuclear NK3R redistribution in dopaminergic neurons of the rat ventral tegmental area.

Pub. Date : 2013 Sep 5

PMID : 23673279






7 Functional Relationships(s)
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1 The neurokinin-3 receptor (NK3R) antagonist SB222200 prevents the apomorphine-evoked surface but not nuclear NK3R redistribution in dopaminergic neurons of the rat ventral tegmental area. SB 222200 tachykinin receptor 3 Rattus norvegicus
2 The neurokinin-3 receptor (NK3R) antagonist SB222200 prevents the apomorphine-evoked surface but not nuclear NK3R redistribution in dopaminergic neurons of the rat ventral tegmental area. SB 222200 tachykinin receptor 3 Rattus norvegicus
3 In DA (TH-labeled) dendrites, VTA microinjection of SB222200 prevented the apomorphine-evoked decrease in surface NK3R density as well as the apomorphine-induced increase in cytoplasmic NK3R density. SB 222200 tachykinin receptor 3 Rattus norvegicus
4 In DA (TH-labeled) dendrites, VTA microinjection of SB222200 prevented the apomorphine-evoked decrease in surface NK3R density as well as the apomorphine-induced increase in cytoplasmic NK3R density. SB 222200 tachykinin receptor 3 Rattus norvegicus
5 The results suggest that the NK3R antagonist SB222200 is effective against the apomorphine-evoked NK3R internalization in VTA DA dendrites, but does not prevent nuclear NK3R trafficking in VTA DA neurons. SB 222200 tachykinin receptor 3 Rattus norvegicus
6 The results suggest that the NK3R antagonist SB222200 is effective against the apomorphine-evoked NK3R internalization in VTA DA dendrites, but does not prevent nuclear NK3R trafficking in VTA DA neurons. SB 222200 tachykinin receptor 3 Rattus norvegicus
7 The results suggest that the NK3R antagonist SB222200 is effective against the apomorphine-evoked NK3R internalization in VTA DA dendrites, but does not prevent nuclear NK3R trafficking in VTA DA neurons. SB 222200 tachykinin receptor 3 Rattus norvegicus