Title : A novel function of novobiocin: disrupting the interaction of HIF 1α and p300/CBP through direct binding to the HIF1α C-terminal activation domain.

Pub. Date : 2013

PMID : 23671581






1 Functional Relationships(s)
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1 Here, we document, for the first time, that the aminocoumarin antibiotic, novobiocin, directly blocks the protein-protein interaction between the HIF1alpha C-terminal activation domain (CTAD) and the cysteine-histidine rich (CH1) region of p300/CBP. Histidine CREB binding protein Homo sapiens