Title : Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells.

Pub. Date : 2013 May 10

PMID : 23663483






1 Functional Relationships(s)
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1 The anti-proliferative actions of metformin were associated with an activation of AMP-activated protein kinase AMPKThr172 together with an inhibition of the insulin/insulin-like growth factor-I (IGF-I) receptor activation and downstream signalling mediators IRS-1 and phosphorylated Akt. Metformin AKT serine/threonine kinase 1 Homo sapiens