Title : Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells.

Pub. Date : 2013

PMID : 23658787






1 Functional Relationships(s)
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1 Whilst direct PPARgamma-agonism promoted cholesterol efflux from THP-1 derived foam cells by 37.7+-3.1% (P<0.01) and stimulated transcription of LXRalpha by 87.9+-9.5% (P<0.001) and ABCG1 by 101.2+-15.5% (P<0.01), NA showed no effect in foam cells on either cholesterol efflux or key RCT genes transcription. Cholesterol nuclear receptor subfamily 1 group H member 3 Homo sapiens