Title : Chemotherapeutic alteration of VEGF, PDGF and PDGFRα/β expression under 5-FU vs. docetaxel in HPV-transformed squamous cell carcinoma compared to HPV-negative HNSCC in vitro.

Pub. Date : 2013 May

PMID : 23645743






2 Functional Relationships(s)
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1 Chemotherapeutic alteration of VEGF, PDGF and PDGFRalpha/beta expression under 5-FU vs. docetaxel in HPV-transformed squamous cell carcinoma compared to HPV-negative HNSCC in vitro. Fluorouracil vascular endothelial growth factor A Homo sapiens
2 RESULTS: We demonstrated a significant reduction of VEGF and PDGFRbeta expression after incubation with docetaxel by ELISA and of PDGF by immunohistochemistry, irrespective of the HPV status, whereas the application of 5-FU had a significantly weaker impact on the expression of angiogenic peptides. Fluorouracil vascular endothelial growth factor A Homo sapiens