Pub. Date : 2013 May 2
PMID : 23638734
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1alpha and NFkappaB, and VEGF expression. | epigallocatechin gallate | vascular endothelial growth factor A | Mus musculus |
| 2 | The present study tests the hypothesis that EGCG can inhibit the activation of HIF-1alpha and NFkappaB, and VEGF expression, thereby suppressing tumor angiogenesis and breast cancer progression. | epigallocatechin gallate | vascular endothelial growth factor A | Mus musculus |
| 3 | EGCG treatment significantly reduced tumor weight over the control (0.37 +- 0.15 vs. 1.16 +- 0.30 g; P < 0.01), tumor CD (109 +- 20 vs. 156 +- 12 capillary #/mm^2; P < 0.01), tumor VEGF expression (45.72 +- 1.4 vs. 59.03 +- 3.8 pg/mg; P < 0.01), respectively. | epigallocatechin gallate | vascular endothelial growth factor A | Mus musculus |
| 4 | EGCG at 50 mug/ml significantly inhibited the activation of HIF-1alpha and NFkappaB as well as VEGF expression in cultured E0771 cells, compared to the control, respectively. | epigallocatechin gallate | vascular endothelial growth factor A | Mus musculus |
| 5 | These findings support the hypothesis that EGCG, a major green tea catechin, directly targets both tumor cells and tumor vasculature, thereby inhibiting tumor growth, proliferation, migration, and angiogenesis of breast cancer, which is mediated by the inhibition of HIF-1alpha and NFkappaB activation as well as VEGF expression. | epigallocatechin gallate | vascular endothelial growth factor A | Mus musculus |