Title : Aconitase causes iron toxicity in Drosophila pink1 mutants.

Pub. Date : 2013 Apr

PMID : 23637640






1 Functional Relationships(s)
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1 Using Acon enzymatic mutants, and expression of mitoferritin that scavenges free iron, we show that [4Fe-4S] cluster inactivation, as a result of increased superoxide in pink1 mutants, results in oxidative stress and mitochondrial swelling. Superoxides PTEN-induced putative kinase 1 Drosophila melanogaster