Title : [Efficiency of trimetazidine treatment of experimental ischemic heart disease in age aspect].

Pub. Date : 2013

PMID : 23631276






1 Functional Relationships(s)
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1 Introduction of trimetazidine to 10-month-aged rats with experimental ischemic heart disease leads to an increase in carbohydrate utilization with energy purposes in myocardium, which is manifested by increasing activity of glycolysis enzymes with decreasing lactate level in myocardium, increasing activity of pyruvate dehydrogenase and citrate synthase in mitochondrial cardiomyocytes, and increasing ATP content in myocardium. Trimetazidine citrate synthase Rattus norvegicus