Title : [The effect of PNS on the content and activity of alpha-secretase in the brains of SAMP8 mice with alzheimer's disease].

Pub. Date : 2012 Nov

PMID : 23627094






3 Functional Relationships(s)
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1 The results of western blot showed that the level of ADAM9 protein expression in PNS high-dosage, low-dosage and huperzine A groups was significantly higher than that of control group (P < 0.05) while the levels of ADAM10 protein expression in PNS high-dosage, low-dosage and huperzine A groups was significantly lower than that of control group (P < 0.05), while level of ADAM17 of huperzine A group was higher than that of control group (P < 0.05). huperzine A a disintegrin and metallopeptidase domain 9 (meltrin gamma) Mus musculus
2 The results of western blot showed that the level of ADAM9 protein expression in PNS high-dosage, low-dosage and huperzine A groups was significantly higher than that of control group (P < 0.05) while the levels of ADAM10 protein expression in PNS high-dosage, low-dosage and huperzine A groups was significantly lower than that of control group (P < 0.05), while level of ADAM17 of huperzine A group was higher than that of control group (P < 0.05). huperzine A a disintegrin and metallopeptidase domain 9 (meltrin gamma) Mus musculus
3 The results of western blot showed that the level of ADAM9 protein expression in PNS high-dosage, low-dosage and huperzine A groups was significantly higher than that of control group (P < 0.05) while the levels of ADAM10 protein expression in PNS high-dosage, low-dosage and huperzine A groups was significantly lower than that of control group (P < 0.05), while level of ADAM17 of huperzine A group was higher than that of control group (P < 0.05). huperzine A a disintegrin and metallopeptidase domain 9 (meltrin gamma) Mus musculus