Title : Involvement of dorsal hippocampal and medial septal nicotinic receptors in cross state-dependent memory between WIN55, 212-2 and nicotine or ethanol in mice.

Pub. Date : 2013 Aug 15

PMID : 23624371






3 Functional Relationships(s)
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1 The present study examined whether nicotinic acetylcholine receptors (nAChRs) of the CA1 regions of the dorsal hippocampus and medial septum (MS) are involved in cross state-dependent memory retrieval between WIN55, 212-2 (WIN, a non-selective CB1/CB2 receptor agonist) and nicotine or ethanol. Nicotine carbonic anhydrase 1 Mus musculus
2 Pre-test intra-CA1 microinjection of nicotine (1 and 2mug/mouse) before systemic administration of an ineffective dose of nicotine (0.5mg/kg, s.c.) or ethanol (0.25g/kg) significantly reversed WIN-induced memory impairment. Nicotine carbonic anhydrase 1 Mus musculus
3 Pre-test intra-CA1 microinjection of mecamylamine (1 and 3mug/mouse) inhibited cross state-dependent memory between WIN and nicotine or ethanol. Nicotine carbonic anhydrase 1 Mus musculus