Title : A high-fat diet and multiple administration of carbon tetrachloride induces liver injury and pathological features associated with non-alcoholic steatohepatitis in mice.

Pub. Date : 2013 Jul

PMID : 23611112






2 Functional Relationships(s)
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1 However, the multiple administration of CCl4 to obese mice reduced the ratio of reduced glutathione to oxidized glutathione, superoxide dismutase activity and mitochondrial DNA copy number, leading to the development of chronic oxidative stress, increased numbers of apoptotic cells and increased levels of both tumour necrosis factor-alpha and transforming growth factor-beta mRNA. Glutathione chemokine (C-C motif) ligand 4 Mus musculus
2 However, the multiple administration of CCl4 to obese mice reduced the ratio of reduced glutathione to oxidized glutathione, superoxide dismutase activity and mitochondrial DNA copy number, leading to the development of chronic oxidative stress, increased numbers of apoptotic cells and increased levels of both tumour necrosis factor-alpha and transforming growth factor-beta mRNA. Glutathione chemokine (C-C motif) ligand 4 Mus musculus