Title : Exendin-4 protects murine MIN6 pancreatic β-cells from interleukin-1β-induced apoptosis via the NF-κB pathway.

Pub. Date : 2013 Nov

PMID : 23609920






2 Functional Relationships(s)
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1 RESULTS: IL-1beta treatment (range, 5-40 ng/ml) for 24 h was positively correlated with nitrite production (R2=0.9668, p<0.01), a significant increase in the percentage of apoptotic cells (p<0.01) and a concomitant dose-dependent increase in cytoplasmic levels of iNOS and NF-kappaB p65 activation. Nitrites interleukin 1 beta Mus musculus
2 CONCLUSIONS: These results suggest that exendin-4 protects against IL-1beta- induced apoptosis in beta-cells via downregulation of the NF- kappaB-iNOS-nitrite pathway. Nitrites interleukin 1 beta Mus musculus