Title : Cyclooxygenase-2-derived prostaglandin E₂ promotes injury-induced vascular neointimal hyperplasia through the E-prostanoid 3 receptor.

Pub. Date : 2013 Jul 5

PMID : 23595951






1 Functional Relationships(s)
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1 CONCLUSIONS: COX-2-derived PGE2 facilitated the neointimal hyperplasia response to injury through EP3alpha/beta-mediated cAMP/protein kinase A and phosphatidylinositol 3-kinase pathways, indicating EP3 inhibition may be a promising therapeutic strategy for percutaneous transluminal coronary angioplasty. Dinoprostone prostaglandin E receptor 3 (subtype EP3) Mus musculus