Pub. Date : 2013 Aug
PMID : 23594678
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro, NOD2 induced proinflammatory response and impaired insulin signaling and insulin-induced glucose uptake in podocytes. | Glucose | nucleotide-binding oligomerization domain containing 2 | Mus musculus |
| 2 | Moreover, podocytes treated with high glucose, advanced glycation end-products, tumor necrosis factor-alpha, or transforming growth factor-beta (common detrimental factors in diabetic nephropathy) significantly increased NOD2 expression. | Glucose | nucleotide-binding oligomerization domain containing 2 | Mus musculus |
| 3 | Further, knockdown of NOD2 expression attenuated high glucose-induced nephrin downregulation in vitro, supporting an essential role of NOD2 in mediating hyperglycemia-induced podocyte dysfunction. | Glucose | nucleotide-binding oligomerization domain containing 2 | Mus musculus |
| 4 | Further, knockdown of NOD2 expression attenuated high glucose-induced nephrin downregulation in vitro, supporting an essential role of NOD2 in mediating hyperglycemia-induced podocyte dysfunction. | Glucose | nucleotide-binding oligomerization domain containing 2 | Mus musculus |