Pub. Date : 2013 Jun
PMID : 23588680
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | All-trans retinoic acid upregulates the expression of p53 via Axin and inhibits the proliferation of glioma cells. | Tretinoin | tumor protein p53 | Homo sapiens |
| 2 | In the present study, we demonstrated that ATRA activated the expression of p53 via Axin and induced cell cycle arrest at the G1/S phase and apoptosis of glioma cells. | Tretinoin | tumor protein p53 | Homo sapiens |
| 3 | Furthermore, loss-of-function of Axin in glioma cells by RNAi blocked ATRA-induced cell cycle phase arrest and apoptosis via downregulation of p53. | Tretinoin | tumor protein p53 | Homo sapiens |