Title : Effects of glycosylation and pH conditions in the dynamics of human arylsulfatase A.

Pub. Date : 2014 Apr

PMID : 23581857






1 Functional Relationships(s)
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1 In this work, we have investigated ARSA dynamics employing molecular dynamics simulations in response to (1) different pH"s, as, beyond its natural lysossomal environment, it has been recently identified in cytoplasmatic medium and (2) glycan occupancies, including its normal glycosylation state, presenting three high mannose-type oligosaccharides. Oligosaccharides arylsulfatase A Homo sapiens