Title : A chemically-modified inactive antithrombin as a potent antagonist of fondaparinux and heparin anticoagulant activity.

Pub. Date : 2013 Jun

PMID : 23581397






3 Functional Relationships(s)
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1 METHODS: Plasma-derived AT was chemically modified with 2,3 butanedione, a diketone known to specifically react with the arginine side chain. Diacetyl serpin family C member 1 Homo sapiens
2 RESULTS: AT treated by butanedione and selected for its high heparin affinity (AT-BD) was indeed modified on reactive Arg393 and thus exhibited decreased anticoagulant activity and increased heparin affinity. Diacetyl serpin family C member 1 Homo sapiens
3 RESULTS: AT treated by butanedione and selected for its high heparin affinity (AT-BD) was indeed modified on reactive Arg393 and thus exhibited decreased anticoagulant activity and increased heparin affinity. Diacetyl serpin family C member 1 Homo sapiens