Pub. Date : 2013 Jul
PMID : 23579097
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The combined treatment with BLU and gemcitabine further activated p53 and p21 expression, whereas the productions of Bcl-2, Bcl-xL, and nuclear factor-kappa B proteins were decreased, with BLU possibly being more effective in the treatment of ovarian cancer when given in combination with gemcitabine, rather than as a single agent. | gemcitabine | tumor protein p53 | Homo sapiens |
| 2 | Taken together, our results provide evidence that BLU can effectively regulate the pro-apoptotic and anti-angiogenic activity of gemcitabine through the direct interaction with vascular endothelial growth factor receptor-2, as well as the up-regulation of p21 and p53 expression. | gemcitabine | tumor protein p53 | Homo sapiens |