Pub. Date : 2013 Nov
PMID : 23568147
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Importantly, leukemic cells with high basal AKT phosphorylation, glucose consumption or glycolysis exhibit a markedly reduced induction of the Pasteur effect in response to metformin and are resistant to metformin-induced apoptosis. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Importantly, leukemic cells with high basal AKT phosphorylation, glucose consumption or glycolysis exhibit a markedly reduced induction of the Pasteur effect in response to metformin and are resistant to metformin-induced apoptosis. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Accordingly, glucose starvation or treatment with deoxyglucose or an AKT inhibitor induces sensitivity to metformin. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Overall, metformin elicits reprogramming of intermediary metabolism leading to inhibition of cell proliferation in all leukemic cells and apoptosis only in leukemic cells responding to metformin with AKT phosphorylation and a strong Pasteur effect. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | Overall, metformin elicits reprogramming of intermediary metabolism leading to inhibition of cell proliferation in all leukemic cells and apoptosis only in leukemic cells responding to metformin with AKT phosphorylation and a strong Pasteur effect. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |