Title : Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression.

Pub. Date : 2013 Jul 1

PMID : 23566837






1 Functional Relationships(s)
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1 Western blotting showed decreased expression of phosphorylated mTOR and phosphorylated p70S6K in the rapamycin-treated group, and increased the expression of both SIRT1 and SIRT6 compared to the control group (P<0.05). Sirolimus ribosomal protein S6 kinase B1 Rattus norvegicus