Title : NAAG peptidase inhibitor improves motor function and reduces cognitive dysfunction in a model of TBI with secondary hypoxia.

Pub. Date : 2013 Jun 17

PMID : 23562458






3 Functional Relationships(s)
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1 However, the catalytic enzyme glutamate carboxypeptidase II (GCP II) rapidly hydrolyzes NAAG into NAA and glutamate. 1-naphthaleneacetic acid folate hydrolase 1 Rattus norvegicus
2 However, the catalytic enzyme glutamate carboxypeptidase II (GCP II) rapidly hydrolyzes NAAG into NAA and glutamate. 1-naphthaleneacetic acid folate hydrolase 1 Rattus norvegicus
3 Inhibition of the GCP II enzyme with NAAG peptidase inhibitors reduces the concentration of glutamate both by increasing the duration of NAAG activity on mGluR3 and by reducing degradation into NAA and glutamate resulting in reduced cell death in models of TBI and TBI with hypoxia. 1-naphthaleneacetic acid folate hydrolase 1 Rattus norvegicus