Pub. Date : 2013
PMID : 23555949
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Zoledronic acid produces combinatory anti-tumor effects with cisplatin on mesothelioma by increasing p53 expression levels. | Zoledronic Acid | tumor protein p53 | Homo sapiens |
| 2 | ZOL-treated cells as well as CDDP-treated cells induced p53 phosphorylation at Ser 15, a marker of p53 activation, and up-regulated p53 protein expression levels. | Zoledronic Acid | tumor protein p53 | Homo sapiens |
| 3 | ZOL-treated cells as well as CDDP-treated cells induced p53 phosphorylation at Ser 15, a marker of p53 activation, and up-regulated p53 protein expression levels. | Zoledronic Acid | tumor protein p53 | Homo sapiens |
| 4 | ZOL-treated cells as well as CDDP-treated cells induced p53 phosphorylation at Ser 15, a marker of p53 activation, and up-regulated p53 protein expression levels. | Zoledronic Acid | tumor protein p53 | Homo sapiens |
| 5 | Down-regulation of p53 levels with siRNA however did not influence the ZOL-mediated cytotoxicity but negated the combinatory effects by ZOL and CDDP. | Zoledronic Acid | tumor protein p53 | Homo sapiens |
| 6 | These data demonstrated that ZOL-mediated augmentation of p53, which was not linked with ZOL-induced cytotoxicity, played a role in the combinatory effects with a p53 up-regulating agent, and suggests a possible clinical use of ZOL to mesothelioma with anti-cancer agents. | Zoledronic Acid | tumor protein p53 | Homo sapiens |
| 7 | These data demonstrated that ZOL-mediated augmentation of p53, which was not linked with ZOL-induced cytotoxicity, played a role in the combinatory effects with a p53 up-regulating agent, and suggests a possible clinical use of ZOL to mesothelioma with anti-cancer agents. | Zoledronic Acid | tumor protein p53 | Homo sapiens |