Title : Hyperglycemia magnifies bupivacaine-induced cell apoptosis triggered by mitochondria dysfunction and endoplasmic reticulum stress.

Pub. Date : 2013 Jun

PMID : 23553889






1 Functional Relationships(s)
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1 Incubation with bupivacaine decreased the activity of mitochondrial complexes I and III; increased ROS production at cell and mitochondrial levels, mitochondrial potential depolarization, and Grp78 and caspase-12 expression at both transcription and translation levels; and affected cell structure, which could be enhanced by glucose pretreatment. Bupivacaine heat shock protein family A (Hsp70) member 5 Homo sapiens