Title : Prenatal ethanol exposure causes glucose intolerance with increased hepatic gluconeogenesis and histone deacetylases in adult rat offspring: reversal by tauroursodeoxycholic acid.

Pub. Date : 2013

PMID : 23544086






2 Functional Relationships(s)
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1 Conversely, prenatal ethanol reduced acetylation of foxo1 and PEPCK. Ethanol forkhead box O1 Rattus norvegicus
2 Thus, prenatal exposure of rats to ethanol results in long lasting oxidative and endoplasmic reticulum stresses explaining increased expression of gluconeogenic genes and HDAC proteins which, by deacetylating foxo1 and PEPCK, contribute to increased gluconeogenesis. Ethanol forkhead box O1 Rattus norvegicus