Pub. Date : 2013
PMID : 23544048
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that curcumin inhibited the EMT as assessed by reduced expression of alpha-SMA and PAI-1, and increased E-cadherin in TGF-beta1 treated proximal tubular epithelial cell HK-2 cells. | Curcumin | transforming growth factor beta 1 | Homo sapiens |
| 2 | On the other hand, in non-Smad pathway curcumin reduced TGF-beta1-induced ERK phosphorylation and PPARgamma phosphorylation, and promoted nuclear translocation of PPARgamma. | Curcumin | transforming growth factor beta 1 | Homo sapiens |
| 3 | We conclude that curcumin counteracted TGF-beta1-induced EMT in renal tubular epithelial cells via ERK-dependent and then PPARgamma-dependent pathway. | Curcumin | transforming growth factor beta 1 | Homo sapiens |