Title : Sorafenib enhances proteasome inhibitor-induced cell death via inactivation of Akt and stress-activated protein kinases.

Pub. Date : 2014 Mar

PMID : 23543326






3 Functional Relationships(s)
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1 RESULTS: Both sorafenib and proteasome inhibitors induced apoptosis in Huh7 and OUMS29. Sorafenib MIR7-3 host gene Homo sapiens
2 Sorafenib induced down-regulation of Akt synergistically in combination with proteasome inhibitors in Huh7. Sorafenib MIR7-3 host gene Homo sapiens
3 In addition, sorafenib also inhibited proteasome inhibitor-mediated JNK and p38 activation in both Huh7 and OUMS29. Sorafenib MIR7-3 host gene Homo sapiens