Title : Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Pub. Date : 2013 Apr 4

PMID : 23535601






1 Functional Relationships(s)
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1 Whereas most cells use glutamate dehydrogenase (GLUD1) to convert glutamine-derived glutamate into alpha-ketoglutarate in the mitochondria to fuel the tricarboxylic acid cycle, PDAC relies on a distinct pathway in which glutamine-derived aspartate is transported into the cytoplasm where it can be converted into oxaloacetate by aspartate transaminase (GOT1). Tricarboxylic Acids glutamate dehydrogenase 1 Homo sapiens