Title : Long-acting β2-agonists increase fluticasone propionate-induced mitogen-activated protein kinase phosphatase 1 (MKP-1) in airway smooth muscle cells.

Pub. Date : 2013

PMID : 23533638






2 Functional Relationships(s)
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1 To address this, we investigated MKP-1 gene expression and protein upregulation induced by two long-acting beta2-agonists (salmeterol and formoterol), alone or in combination with the corticosteroid fluticasone propionate (abbreviated as fluticasone) in primary human airway smooth muscle (ASM) cells in vitro. Formoterol Fumarate dual specificity phosphatase 1 Homo sapiens
2 As IL-6 expression (like MKP-1) is cAMP/adenylate cyclase-mediated, the long-acting beta2-agonist formoterol increased IL-6 mRNA expression and secretion. Formoterol Fumarate dual specificity phosphatase 1 Homo sapiens