Pub. Date : 2013 Mar
PMID : 23531921
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo. | AZD 1480 | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | Our data indicate that AZD1480 blocks endogenous as well as IL-6 induced STAT3 activation. | AZD 1480 | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | AZD1480 induces cell growth inhibition and caspase-dependent apoptosis in vitro and decreases expression of STAT3 target genes, including cell cycle regulators CyclinD1, 3 and CDC25A, anti-apoptotic genes Bcl-2 and survivin, the metastasis-related factor TIMP-1 and c-Myc. | AZD 1480 | signal transducer and activator of transcription 3 | Mus musculus |
| 4 | Tumors from AZD1480-treated mice showed inhibition of activated STAT3 as well as decreased expression of STAT3 downstream targets. | AZD 1480 | signal transducer and activator of transcription 3 | Mus musculus |
| 5 | Tumors from AZD1480-treated mice showed inhibition of activated STAT3 as well as decreased expression of STAT3 downstream targets. | AZD 1480 | signal transducer and activator of transcription 3 | Mus musculus |
| 6 | Our study provides strong evidence of the anti-tumor growth potency of JAK inhibitor AZD1480 in pediatric solid tumors, providing proof-of principle that inhibition of the JAK/STAT3 signal transduction could be a promising therapeutic target for high-risk pediatric solid tumors. | AZD 1480 | signal transducer and activator of transcription 3 | Mus musculus |