Title : Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo.

Pub. Date : 2013 Mar

PMID : 23531921






1 Functional Relationships(s)
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Protein Name
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1 AZD1480 induces cell growth inhibition and caspase-dependent apoptosis in vitro and decreases expression of STAT3 target genes, including cell cycle regulators CyclinD1, 3 and CDC25A, anti-apoptotic genes Bcl-2 and survivin, the metastasis-related factor TIMP-1 and c-Myc. AZD 1480 B cell leukemia/lymphoma 2 Mus musculus