Title : Mechanisms underlying protective effects of trimetazidine on endothelial progenitor cells biological functions against H2O2-induced injury: involvement of antioxidation and Akt/eNOS signaling pathways.

Pub. Date : 2013 May 5

PMID : 23528356






4 Functional Relationships(s)
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1 Mechanisms underlying protective effects of trimetazidine on endothelial progenitor cells biological functions against H2O2-induced injury: involvement of antioxidation and Akt/eNOS signaling pathways. Trimetazidine AKT serine/threonine kinase 1 Homo sapiens
2 The results showed that pretreatment of EPCs with TMZ (10 microM) protected the proliferation, adhesion, migration, and apoptosis of EPCs against H2O2, accompanied by an increase in superoxide dismutase (SOD) activity, a decrease in malonaldehyde (MDA) content, and increases in eNOS, Akt phosphorylation, and NO production. Trimetazidine AKT serine/threonine kinase 1 Homo sapiens
3 These TMZ-mediated beneficial effects on EPCs could be attenuated by pre-incubation with the Akt inhibitor triciribine. Trimetazidine AKT serine/threonine kinase 1 Homo sapiens
4 In conclusion, the present study demonstrates that TMZ ameliorated H2O2-induced impairment of biological functions in EPCs with the involvement of antioxidation and Akt/eNOS signaling pathway. Trimetazidine AKT serine/threonine kinase 1 Homo sapiens