Title : Inhibition of formyl peptide-stimulated phospholipase D activation by Fal-002-2 via blockade of the Arf6, RhoA and protein kinase C signaling pathways in rat neutrophils.

Pub. Date : 2013 Jun

PMID : 23525454






1 Functional Relationships(s)
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1 Fal-002-2 attenuated the interaction of PLD1 with ADP-ribosylation factor (Arf) 6, Ras homology (Rho) A and protein kinase C (PKC) isoforms (alpha, betaI, and betaII), and also inhibited the membrane recruitment of Arf6 and RhoA in fMLP-stimulated neutrophils, but not in GTPgammaS-stimulated cell-free system. Guanosine 5'-O-(3-Thiotriphosphate) phospholipase D1 Rattus norvegicus