Title : Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.

Pub. Date : 2013 Jan 16

PMID : 23525442






2 Functional Relationships(s)
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1 In vivo, RAGE inhibition in monocrotaline- and Sugen-induced PAH demonstrates therapeutic effects characterized by PA pressure and right ventricular hypertrophy decrease (control rats have an mPAP around 15 mm Hg, PAH rats have an mPAP >40 mm Hg, and with RAGE inhibition, mPAP decreases to 20 and 28 mm Hg, respectively, in MCT and Sugen models). Protactinium phospholipid phosphatase 1 Mus musculus
2 In vivo, RAGE inhibition in monocrotaline- and Sugen-induced PAH demonstrates therapeutic effects characterized by PA pressure and right ventricular hypertrophy decrease (control rats have an mPAP around 15 mm Hg, PAH rats have an mPAP >40 mm Hg, and with RAGE inhibition, mPAP decreases to 20 and 28 mm Hg, respectively, in MCT and Sugen models). Protactinium phospholipid phosphatase 1 Mus musculus