Title : MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor.

Pub. Date : 2013 Jun 7

PMID : 23519696






4 Functional Relationships(s)
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1 Overexpression of miR-144 in vitro decreased both cellular ABCA1 protein and cholesterol efflux to lipid-poor apolipoprotein A-I protein, whereas overexpression in vivo reduced hepatic ABCA1 protein and plasma HDL-cholesterol. Cholesterol microRNA 144 Mus musculus
2 Overexpression of miR-144 in vitro decreased both cellular ABCA1 protein and cholesterol efflux to lipid-poor apolipoprotein A-I protein, whereas overexpression in vivo reduced hepatic ABCA1 protein and plasma HDL-cholesterol. Cholesterol microRNA 144 Mus musculus
3 Conversely, silencing miR-144 in mice increased hepatic ABCA1 protein and HDL-cholesterol. Cholesterol microRNA 144 Mus musculus
4 CONCLUSIONS: We have identified a novel pathway involving FXR, miR-144, and ABCA1 that together regulate plasma HDL-cholesterol. Cholesterol microRNA 144 Mus musculus