Title : Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1.

Pub. Date : 2013 Mar 21

PMID : 23519122






1 Functional Relationships(s)
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1 Presently, the impaired cellular availability of vitamin B12 in TO cells activated irreversible ER stress pathways, with increased P-eIF-2alpha, P-PERK, P-IRE1alpha, ATF6, ATF4, decreased chaperon proteins and increased pro-apoptotic markers, CHOP and cleaved caspase 3, through reduced SIRT1 expression and consequently greater acetylation of heat-shock factor protein 1 (HSF1). Vitamin B 12 activating transcription factor 6 Mus musculus