Title : [Effect of thalidomide in a mouse model of paraquat-induced acute lung injury and the underlying mechanisms].

Pub. Date : 2013 Mar

PMID : 23510834






2 Functional Relationships(s)
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1 Compared with the paraquat poisoning group, the thalidomide treatment groups had significantly decreased levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65 and wet/dry ratios of the lung (P < 0.05), and the 150 mg/kg thalidomide treatment group showed the most significant decrease in the levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65. Thalidomide interleukin 1 beta Mus musculus
2 Compared with the paraquat poisoning group, the thalidomide treatment groups had significantly decreased levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65 and wet/dry ratios of the lung (P < 0.05), and the 150 mg/kg thalidomide treatment group showed the most significant decrease in the levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65. Thalidomide interleukin 1 beta Mus musculus